Publications

Sprague Lab Publications

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Postdoctoral

TRP drop, TRP drop: a steady patter of anti-schistosomal target illumination

Daniel J. Sprague#, Claudia M. Rohr#, Jonathan S. Marchant

Frontiers in Parasitology, 2024

Target-based discovery of a broad spectrum flukicide

Daniel J. Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M. Rohr, Evgeny G. Chulkov, Emery Smith, Louis Scampavia, Timothy P. Spicer, Simone Haeberlein, Jonathan S. Marchant

Nature Structural and Molecular Biology, 2024

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types

Rachel A. Jones Lipinski, Jennifer S. Stancill, Raymundo Nunez, Sarah L. Wynia-Smith, Daniel J. Sprague, Joshua A. Nord, Amir Bird, John A. Corbett, Brian C. Smith

American Journal of Physiology -- Regulatory, Integrative and Comparative Physiology, 2024

The anthelmintic meclonazepam activates a schistosome transient receptor potential channel

Sang-Kyu Park#, Daniel J. Sprague#, Claudia M. Rohr, Evgeny G. Chulkov, Ian Petrow, Sushil Kumar, Jonathan S. Marchant

Journal of Biological Chemistry, 2024

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

Claudia M. Rohr, Daniel J. Sprague, Sang-Kyu Park, Nicholas J. Malcolm, Jonathan S. Marchant

Proceedings of the National Academy of Sciences, 2023

The anthelmintic activity of praziquantel analogs correlates with different structure-activity relationships at TRPMPZQ orthologs

Daniel J. Sprague*, Marc Kaethner, Sang-Kyu Park, Claudia M. Rohr, Jade L. Harris, David Maillard, Thomas Spangenberg, Britta Lundstrom-Stadelmann, Jonathan S. Marchant*

ACS Medicinal Chemistry Letters, 2023

Molecular and cellular basis of praziquantel action in the cardiovascular system

Nawal A. Yahya, Janelle K. Lanham, Daniel J. Sprague, Oleg Palygin, John D. McCorvy, Jonathan S. Marchant

American Journal of Physiology -- Cell Physiology, 2023

Mu-Opioid Receptor Selective Superagonists Produce Prolonged Respiratory Depression

Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy

iSCIENCE, 2023

Identification of a dihydropyridine scaffold that blocks ryanodine receptors

Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant

iSCIENCE, 2022

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

Mahmoud AbuEid, Robert F. Keyes, Donna McAllister, Francis Peterson, Ishaque Pulikkal Kadamberi, Daniel J. Sprague, Pradeep Chaluvally-Raghavan, Brian C. Smith, Michael B. Dwinell

iSCIENCE, 2022

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12

Daniel J. Sprague, Anthony E. Getschman, Tyler G. Fenske, Brian F. Volkman, Brian C. Smith

ACS Medicinal Chemistry Letters, 2021

Development of activity-based probes for the protein deacylase Sirt1

Christopher J. Goetz, Daniel J. Sprague, Brian C. Smith

Bioorganic Chemistry, 2020

Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites

Michael D. Olp, Daniel J. Sprague, Christopher J. Goetz, Stefan G. Kathman, Sarah L. Wynia-Smith, Shifali Shishodia, Steven B. Summers, Ziyang Xu, Alexander V. Statsyuk, Brian C. Smith

ACS Chemical Biology, 2020